Ontology highlight
ABSTRACT:
SUBMITTER: Waisfisz Q
PROVIDER: S-EPMC1377877 | biostudies-other | 1999 May
REPOSITORIES: biostudies-other
Waisfisz Q Q Saar K K Morgan N V NV Altay C C Leegwater P A PA de Winter J P JP Komatsu K K Evans G R GR Wegner R D RD Reis A A Joenje H H Arwert F F Mathew C G CG Pronk J C JC Digweed M M
American journal of human genetics 19990501 5
Fanconi anemia (FA) is a genetically heterogeneous autosomal recessive disease with bone marrow failure and predisposition to cancer as major features, often accompanied by developmental anomalies. The cells of patients with FA are hypersensitive to DNA cross-linking agents in terms of cell survival and chromosomal breakage. Of the eight complementation groups (FA-A to FA-H) distinguished thus far by cell fusion studies, the genes for three-FANCA, FANCC, and FANCG-have been identified, and the F ...[more]