Ontology highlight
ABSTRACT:
SUBMITTER: Hejna JA
PROVIDER: S-EPMC1378015 | biostudies-other | 2000 May
REPOSITORIES: biostudies-other
Hejna J A JA Timmers C D CD Reifsteck C C Bruun D A DA Lucas L W LW Jakobs P M PM Toth-Fejel S S Unsworth N N Clemens S L SL Garcia D K DK Naylor S L SL Thayer M J MJ Olson S B SB Grompe M M Moses R E RE
American journal of human genetics 20000412 5
Fanconi anemia (FA) is a rare autosomal recessive disease manifested by bone-marrow failure and an elevated incidence of cancer. Cells taken from patients exhibit spontaneous chromosomal breaks and rearrangements. These breaks and rearrangements are greatly elevated by treatment of FA cells with the use of DNA cross-linking agents. The FA complementation group D gene (FANCD) has previously been localized to chromosome 3p22-26, by use of microcell-mediated chromosome transfer. Here we describe th ...[more]