A genomic screen of autism: evidence for a multilocus etiology.
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ABSTRACT:
SUBMITTER: Risch N
PROVIDER: S-EPMC1377948 | biostudies-other | 1999 Aug
REPOSITORIES: biostudies-other
Publications
A genomic screen of autism: evidence for a multilocus etiology.
Risch N N Spiker D D Lotspeich L L Nouri N N Hinds D D Hallmayer J J Kalaydjieva L L McCague P P Dimiceli S S Pitts T T Nguyen L L Yang J J Harper C C Thorpe D D Vermeer S S Young H H Hebert J J Lin A A Ferguson J J Chiotti C C Wiese-Slater S S Rogers T T Salmon B B Nicholas P P Petersen P B PB Pingree C C McMahon W W Wong D L DL Cavalli-Sforza L L LL Kraemer H C HC Myers R M RM
American journal of human genetics 19990801 2
We have conducted a genome screen of autism, by linkage analysis in an initial set of 90 multiplex sibships, with parents, containing 97 independent affected sib pairs (ASPs), with follow-up in 49 additional multiplex sibships, containing 50 ASPs. In total, 519 markers were genotyped, including 362 for the initial screen, and an additional 157 were genotyped in the follow-up. As a control, we also included in the analysis unaffected sibs, which provided 51 discordant sib pairs (DSPs) for the ini ...[more]
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