Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC1440825 | biostudies-other | 2006 Apr
REPOSITORIES: biostudies-other
Liu Wei W Rui Hongliang H Wang Jifeng J Lin Shuyong S He Ying Y Chen Mingliang M Li Qinxi Q Ye Zhiyun Z Zhang Suping S Chan Siu Chiu SC Chen Ye-Guang YG Han Jiahuai J Lin Sheng-Cai SC
The EMBO journal 20060406 8
TGF-beta signaling involves a wide array of signaling molecules and multiple controlling events. Scaffold proteins create a functional proximity of signaling molecules and control the specificity of signal transduction. While many components involved in the TGF-beta pathway have been elucidated, little is known about how those components are coordinated by scaffold proteins. Here, we show that Axin activates TGF-beta signaling by forming a multimeric complex consisting of Smad7 and ubiquitin E3 ...[more]