HMR-I is an origin of replication and a silencer in Saccharomyces cerevisiae.
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ABSTRACT:
SUBMITTER: Rivier DH
PROVIDER: S-EPMC1460475 | biostudies-other | 1999 Feb
REPOSITORIES: biostudies-other
Publications
HMR-I is an origin of replication and a silencer in Saccharomyces cerevisiae.
Rivier D H DH Ekena J L JL Rine J J
Genetics 19990201 2
There appear to be fundamental differences between the properties of the silencers at HML and HMR, with some being origins of replication and others not. Moreover, past studies have suggested that HMR-I's role in silencing may be restricted to plasmid contexts. This study established that HMR-I, like HMR-E and unlike either HML silencer, is an origin of replication. Moreover, both HMR-E and HMR-I contribute to silencing of a chromosomal HMR locus. In addition, we found that Abf1p plays no unique ...[more]
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