Ontology highlight
ABSTRACT:
SUBMITTER: Begun DJ
PROVIDER: S-EPMC1460974 | biostudies-other | 2000 Mar
REPOSITORIES: biostudies-other
Genetics 20000301 3
NF-kappaB and IkappaB proteins have central roles in regulation of inflammation and innate immunity in mammals. Homologues of these proteins also play an important role in regulation of the Drosophila immune response. Here we present a molecular population genetic analysis of Relish, a Drosophila NF-kappaB/IkappaB protein, in Drosophila simulans and D. melanogaster. We find strong evidence for adaptive protein evolution in D. simulans, but not in D. melanogaster. The adaptive evolution appears t ...[more]