Ontology highlight
ABSTRACT:
SUBMITTER: Huang AM
PROVIDER: S-EPMC1461302 | biostudies-other | 2000 Nov
REPOSITORIES: biostudies-other
Genetics 20001101 3
Differentiation of the R7 photoreceptor cell is dependent on the Sevenless receptor tyrosine kinase, which activates the RAS1/mitogen-activated protein kinase signaling cascade. Kinase suppressor of Ras (KSR) functions genetically downstream of RAS1 in this signal transduction cascade. Expression of dominant-negative KSR (KDN) in the developing eye blocks RAS pathway signaling, prevents R7 cell differentiation, and causes a rough eye phenotype. To identify genes that modulate RAS signaling, we s ...[more]