Ontology highlight
ABSTRACT:
SUBMITTER: Pontier SM
PROVIDER: S-EPMC1500845 | biostudies-other | 2006 Jun
REPOSITORIES: biostudies-other
Pontier Stéphanie M SM Lahaie Nicolas N Ginham Rachel R St-Gelais Fannie F Bonin Hélène H Bell David J DJ Flynn Helen H Trudeau Louis-Eric LE McIlhinney Jeffrey J White Julia H JH Bouvier Michel M
The EMBO journal 20060525 12
The obligatory heterodimerization of the GABAB receptor (GBR) raises fundamental questions about molecular mechanisms controlling its signaling efficacy. Here, we show that NEM sensitive fusion (NSF) protein interacts directly with the GBR heterodimer both in rat brain synaptosomes and in CHO cells, forming a ternary complex that can be regulated by agonist stimulation. Inhibition of NSF binding with a peptide derived from GBR2 (TAT-Pep-27) did not affect basal signaling activity but almost comp ...[more]