Ontology highlight
ABSTRACT:
SUBMITTER: Badou A
PROVIDER: S-EPMC1622857 | biostudies-other | 2006 Oct
REPOSITORIES: biostudies-other
Badou Abdallah A Jha Mithilesh Kumar MK Matza Didi D Mehal Wajahat Z WZ Freichel Marc M Flockerzi Veit V Flavell Richard A RA
Proceedings of the National Academy of Sciences of the United States of America 20061006 42
Calcium ion is a universal signaling intermediate, which is known to control various biological processes. In excitable cells, voltage-gated calcium channels (Cav) are the major route of calcium entry and regulate multiple functions such as contraction, neurotransmitter release, and gene transcription. Here we show that T lymphocytes, which are nonexcitable cells, express both regulatory beta and pore-forming Cav1 alpha1 subunits of Cav channels, and we provide genetic evidence for a critical ro ...[more]