Ontology highlight
ABSTRACT:
SUBMITTER: Werckenthin C
PROVIDER: S-EPMC163571 | biostudies-other | 1996 Nov
REPOSITORIES: biostudies-other
Werckenthin C C Schwarz S S Roberts M C MC
Antimicrobial agents and chemotherapy 19961101 11
Four large staphylococcal plasmids ranging in size from 31 to 82 kbp have been shown to mediate tetracycline resistance via an integrated copy of the tet(K)-encoding plasmid pT181 which was flanked by copies of the insertion element IS257. In two cases, IS257 elements interrupted the repC reading frame of pT181 and an 8-bp sequence from within the repC gene was duplicated at the interrupted site. In the third plasmid, the IS257 elements interrupted the pT181 DNA immediately upstream of the repC ...[more]