Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293.
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ABSTRACT:
SUBMITTER: Charpentier E
PROVIDER: S-EPMC163863 | biostudies-other | 1997 May
REPOSITORIES: biostudies-other
Publications
Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293.
Antimicrobial agents and chemotherapy 19970501 5
The sequence of the trimethoprim resistance gene of the 3.7-kb plasmid (pIP823) that confers high-level resistance (MIC, 1,024 microg/ml) to Listeria monocytogenes BM4293 was determined. The gene was identical to dfrD recently detected in Staphylococcus haemolyticus MUR313. The corresponding protein, S2DHFR, represents the second class of high-level trimethoprim-resistant dihydrofolate reductase identified in gram-positive bacteria. We propose that trimethoprim resistance in L. monocytogenes BM4 ...[more]
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