Ontology highlight
ABSTRACT:
SUBMITTER: White DG
PROVIDER: S-EPMC164191 | biostudies-other | 1997 Dec
REPOSITORIES: biostudies-other
White D G DG Maneewannakul K K von Hofe E E Zillman M M Eisenberg W W Field A K AK Levy S B SB
Antimicrobial agents and chemotherapy 19971201 12
The multiple antibiotic resistance operon (marORAB) in Escherichia coli controls intrinsic susceptibility and resistance to multiple, structurally different antibiotics and other noxious agents. A plasmid construct with marA cloned in the antisense direction reduced LacZ expression from a constitutively expressed marA::lacZ translational fusion and inhibited the induced expression of LacZ in cells bearing the wild-type repressed fusion. The marA antisense construction also decreased the multiple ...[more]