Ontology highlight
ABSTRACT:
SUBMITTER: Damian M
PROVIDER: S-EPMC1698895 | biostudies-other | 2006 Dec
REPOSITORIES: biostudies-other
The EMBO journal 20061130 24
G-protein-coupled receptors (GPCRs) are key players in cell communication. Although long considered as monomeric, it now appears that these heptahelical proteins can form homo- or heterodimers. Here, we analyzed the conformational changes in each subunit of a receptor dimer resulting from agonist binding to either one or both subunits by measuring the fluorescent properties of a leukotriene B(4) receptor dimer with a single 5-hydroxytryptophan-labeled protomer. We show that a receptor dimer with ...[more]