Ontology highlight
ABSTRACT:
SUBMITTER: Frey MR
PROVIDER: S-EPMC1698902 | biostudies-other | 2006 Dec
REPOSITORIES: biostudies-other
Frey Mark R MR Dise Rebecca S RS Edelblum Karen L KL Polk D Brent DB
The EMBO journal 20061130 24
Internalization and proteolytic degradation of epidermal growth factor (EGF) receptor (R) following ligand binding is an important mechanism for regulating EGF-stimulated signals. Using pharmacological and RNA interference inhibition of p38 mitogen-activated protein kinase, we show that p38 is required for efficient EGF-induced EGFR destruction but not internalization. In the absence of p38 activity, EGF fails to stimulate the ubiquitin ligase Cbl or ubiquitinylation of EGFR, and internalized EG ...[more]