Ontology highlight
ABSTRACT:
SUBMITTER: Hyun DH
PROVIDER: S-EPMC1750890 | biostudies-other | 2006 Dec
REPOSITORIES: biostudies-other
Hyun Dong-Hoon DH Emerson Scott S SS Jo Dong-Gyu DG Mattson Mark P MP de Cabo Rafael R de Cabo Rafael R
Proceedings of the National Academy of Sciences of the United States of America 20061213 52
The plasma membrane (PM) contains redox enzymes that provide electrons for energy metabolism and recycling of antioxidants such as coenzyme Q and alpha-tocopherol. Brain aging and neurodegenerative disorders involve impaired energy metabolism and oxidative damage, but the involvement of the PM redox system (PMRS) in these processes is unknown. Caloric restriction (CR), a manipulation that protects the brain against aging and disease, increased activities of PMRS enzymes (NADH-ascorbate free radi ...[more]