Ontology highlight
ABSTRACT:
SUBMITTER: van der Paardt M
PROVIDER: S-EPMC1755451 | biostudies-other | 2005 Apr
REPOSITORIES: biostudies-other
van der Paardt M M Crusius J B A JB García-González M A MA Dijkmans B A C BA Peña A S AS van der Horst-Bruinsma I E IE
Annals of the rheumatic diseases 20050401 4
<h4>Background</h4>Genetic factors are thought to be crucial in the pathogenesis of ankylosing spondylitis. Transforming growth factor beta 1 (TGF beta 1) is a multifunctional cytokine that plays a key role in inflammation. Two functional single nucleotide polymorphisms (SNPs) in the TGFB1 gene have been described: TGFB1 T869C and TGFB1 G915C.<h4>Objective</h4>To determine whether these SNPs contribute to ankylosing spondylitis susceptibility or its disease characteristics.<h4>Methods</h4>Genomi ...[more]