Ontology highlight
ABSTRACT:
SUBMITTER: Begg KJ
PROVIDER: S-EPMC177462 | biostudies-other | 1995 Nov
REPOSITORIES: biostudies-other
Begg K J KJ Dewar S J SJ Donachie W D WD
Journal of bacteriology 19951101 21
A mutation in a newly discovered Escherichia coli cell division gene, ftsK, causes a temperature-sensitive late-stage block in division but does not affect chromosome replication or segregation. This defect is specifically suppressed by deletion of dacA, coding for the peptidoglycan DD-carboxypeptidase, PBP 5. FtsK is a large polypeptide (147 kDa) consisting of an N-terminal domain with several predicted membrane-spanning regions, a proline-glutamine-rich domain, and a C-terminal domain with a n ...[more]