Ontology highlight
ABSTRACT:
SUBMITTER: Kakurai M
PROVIDER: S-EPMC1780201 | biostudies-other | 2006 Nov
REPOSITORIES: biostudies-other
Kakurai Maki M Monteforte Rossella R Suto Hajime H Tsai Mindy M Nakae Susumu S Galli Stephen J SJ
The American journal of pathology 20061101 5
In humans, lesions of contact eczema or atopic dermatitis can exhibit increases in epidermal nerves, but the mechanism resulting in such nerve elongation are not fully understood. We found that contact hypersensitivity reactions to oxazolone in mice were associated with significant increases in the length of nerves in the epidermis and dermis. Using genetically mast cell-deficient c-kit mutant mice selectively repaired of their dermal mast cell deficiency with either wild-type or tumor necrosis ...[more]