Ontology highlight
ABSTRACT:
SUBMITTER: de Crecy-Lagard V
PROVIDER: S-EPMC178751 | biostudies-other | 1997 Feb
REPOSITORIES: biostudies-other
de Crécy-Lagard V V Blanc V V Gil P P Naudin L L Lorenzon S S Famechon A A Bamas-Jacques N N Crouzet J J Thibaut D D
Journal of bacteriology 19970201 3
Two genes involved in the biosynthesis of the depsipeptide antibiotics pristinamycins I (PI) produced by Streptomyces pristinaespiralis were cloned and sequenced. The 1.7-kb snbA gene encodes a 3-hydroxypicolinic acid:AMP ligase, and the 7.7-kb snbC gene encodes PI synthetase 2, responsible for incorporating L-threonine and L-aminobutyric acid in the PI macrocycle. snbA and snbC, which encode the two first structural enzymes of PI synthesis, are not contiguous. Both genes are located in PI-speci ...[more]