Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez MA
PROVIDER: S-EPMC1800806 | biostudies-other | 2007 Jan
REPOSITORIES: biostudies-other
Jimenez Maria A MA Akerblad Peter P Sigvardsson Mikael M Rosen Evan D ED
Molecular and cellular biology 20061023 2
The Ebf (O/E) family of helix-loop-helix transcription factors plays a significant role in B lymphocyte and neuronal development. The three primary members of this family, Ebf1, 2, and 3, are all expressed in adipocytes, and Ebf1 promotes adipogenesis when overexpressed in NIH 3T3 fibroblasts. Here we report that these three proteins have adipogenic potential in multiple cellular models and that peroxisome proliferator-activated receptor gamma (PPARgamma) is required for this effect, at least in ...[more]