Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC1864879 | biostudies-other | 2007 Mar
REPOSITORIES: biostudies-other
Zhang Haifeng H Luo Yan Y Zhang Wei W He Yun Y Dai Shengchuan S Zhang Rong R Huang Yan Y Bernatchez Pascal P Giordano Frank J FJ Shadel Gerald G Sessa William C WC Min Wang W
The American journal of pathology 20070301 3
The function of the mitochondrial antioxidant system thioredoxin (Trx2) in vasculature is not understood. By using endothelial cell (EC)-specific transgenesis of the mitochondrial form of the thioredoxin gene in mice (Trx2 TG), we show the critical roles of Trx2 in regulating endothelium functions. Trx2 TG mice have increased total antioxidants, reduced oxidative stress, and increased nitric oxide (NO) levels in serum compared with their control littermates. Consistently, aortas from Trx2 TG mic ...[more]