Ontology highlight
ABSTRACT:
SUBMITTER: Neyfakh AA
PROVIDER: S-EPMC188464 | biostudies-other | 1992 Feb
REPOSITORIES: biostudies-other
Antimicrobial agents and chemotherapy 19920201 2
The Bacillus subtilis multidrug efflux transporter Bmr demonstrates 44% amino acid sequence identity with a product of the Staphylococcus aureus gene norA, which is responsible for clinically relevant resistance to fluoroquinolones. We show here that overexpression of bmr in B. subtilis provides strong resistance to fluoroquinolones that can be reversed by reserpine, an inhibitor of Bmr. ...[more]