Cell entry by measles virus: long hybrid receptors uncouple binding from membrane fusion.
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ABSTRACT:
SUBMITTER: Buchholz CJ
PROVIDER: S-EPMC190247 | biostudies-other | 1996 Jun
REPOSITORIES: biostudies-other
Publications
Cell entry by measles virus: long hybrid receptors uncouple binding from membrane fusion.
Buchholz C J CJ Schneider U U Devaux P P Gerlier D D Cattaneo R R
Journal of virology 19960601 6
The pH-independent fusion of membranes induced by measles virus (MV) requires, in addition to the fusion-competent protein F, hemagglutinin (H), and on the target membrane, the virus receptor CD46. We constructed hybrid receptors composed of different numbers and combinations of the four CD46 short consensus repeat (SCR) domains, followed by immunoglobulin-like domains of another cell surface protein, CD4. Hybrid proteins containing SCRs I and II bound MV particles and conferred fusion competenc ...[more]
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