Ontology highlight
ABSTRACT:
SUBMITTER: Sarrias MR
PROVIDER: S-EPMC1913855 | biostudies-other | 2007 Jul
REPOSITORIES: biostudies-other
Sarrias Maria-Rosa MR Farnós Montserrat M Mota Rubén R Sánchez-Barbero Fernando F Ibáñez Anna A Gimferrer Idoia I Vera Jorge J Fenutría Rafael R Casals Cristina C Yélamos José J Lozano Francisco F
Proceedings of the National Academy of Sciences of the United States of America 20070629 28
CD6 is a lymphocyte receptor that belongs to the scavenger receptor cysteine-rich superfamily. Because some members of the scavenger receptor cysteine-rich superfamily act as pattern recognition receptors for microbial components, we studied whether CD6 shares this function. We produced a recombinant form of the ectodomain of CD6 (rsCD6), which was indistinguishable (in apparent molecular mass, antibody reactivity, and cell binding properties) from a circulating form of CD6 affinity-purified fro ...[more]