Ontology highlight
ABSTRACT:
SUBMITTER: Harrington ED
PROVIDER: S-EPMC1955820 | biostudies-other | 2007 Aug
REPOSITORIES: biostudies-other
Harrington E D ED Singh A H AH Doerks T T Letunic I I von Mering C C Jensen L J LJ Raes J J Bork P P
Proceedings of the National Academy of Sciences of the United States of America 20070823 35
To assess the potential of protein function prediction in environmental genomics data, we analyzed shotgun sequences from four diverse and complex habitats. Using homology searches as well as customized gene neighborhood methods that incorporate intergenic and evolutionary distances, we inferred specific functions for 76% of the 1.4 million predicted ORFs in these samples (83% when nonspecific functions are considered). Surprisingly, these fractions are only slightly smaller than the correspondi ...[more]