Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.
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ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC1959368 | biostudies-other | 2007 Aug
REPOSITORIES: biostudies-other
Publications
Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.
PLoS pathogens 20070801 8
Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol me ...[more]
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