Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D.
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ABSTRACT:
SUBMITTER: Coon SL
PROVIDER: S-EPMC201756 | biostudies-other | 1994 Aug
REPOSITORIES: biostudies-other
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Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D.
Coon S L SL Kotob S S Jarvis B B BB Wang S S Fuqua W C WC Weiner R M RM
Applied and environmental microbiology 19940801 8
Shewanella colwelliana D is a marine procaryote which produces a diffusible brown pigment that correlates with melA gene expression. Previously, melA had been cloned, sequenced, and expressed in Escherichia coli; however, the reaction product of MelA had not been identified. This report identifies that product as homogentisic acid, provides evidence that the pigment is homogentisic acid-melanin (pyomelanin), and suggests that MelA is p-hydroxyphenylpyruvate hydroxylase. This is the first report ...[more]
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