Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki KG
PROVIDER: S-EPMC2064217 | biostudies-other | 2007 May
REPOSITORIES: biostudies-other
Suzuki Kenichi G N KG Fujiwara Takahiro K TK Edidin Michael M Kusumi Akihiro A
The Journal of cell biology 20070501 4
Clusters of CD59, a glycosylphosphatidylinositol-anchored receptor (GPI-AR), with physiological sizes of approximately six CD59 molecules, recruit Galphai2 and Lyn via protein-protein and raft interactions. Lyn is activated probably by the Galphai2 binding in the same CD59 cluster, inducing the CD59 cluster's binding to F-actin, resulting in its immobilization, termed stimulation-induced temporary arrest of lateral diffusion (STALL; with a 0.57-s lifetime, occurring approximately every 2 s). Sim ...[more]