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Use of the isocitrate dehydrogenase structural gene for attachment of e14 in Escherichia coli K-12.


ABSTRACT: The e14 element appears to be integrated into the Escherichia coli K-12 isocitrate dehydrogenase structural gene (icd). In being integrated, it replaced the last 52 codons of the gene with a closely related sequence. The two versions of the icd gene produce proteins of the same length but differ by 12 base substitutions that would cause two conservative amino acid replacements.

SUBMITTER: Hill CW 

PROVIDER: S-EPMC210168 | biostudies-other | 1989 Jul

REPOSITORIES: biostudies-other

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Use of the isocitrate dehydrogenase structural gene for attachment of e14 in Escherichia coli K-12.

Hill C W CW   Gray J A JA   Brody H H  

Journal of bacteriology 19890701 7


The e14 element appears to be integrated into the Escherichia coli K-12 isocitrate dehydrogenase structural gene (icd). In being integrated, it replaced the last 52 codons of the gene with a closely related sequence. The two versions of the icd gene produce proteins of the same length but differ by 12 base substitutions that would cause two conservative amino acid replacements. ...[more]

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