Ontology highlight
ABSTRACT:
SUBMITTER: Mueller M
PROVIDER: S-EPMC2118403 | biostudies-other | 2006 Sep
REPOSITORIES: biostudies-other
Mueller Matthias M Cima Igor I Noti Mario M Fuhrer Andrea A Jakob Sabine S Dubuquoy Laurent L Schoonjans Kristina K Brunner Thomas T
The Journal of experimental medicine 20060821 9
The nuclear receptor liver receptor homologue-1 (LRH-1, NR5A2) is a crucial transcriptional regulator of many metabolic pathways. In addition, LRH-1 is expressed in intestinal crypt cells where it regulates the epithelial cell renewal and contributes to tumorigenesis through the induction of cell cycle proteins. We have recently identified the intestinal epithelium as an important extra-adrenal source of immunoregulatory glucocorticoids. We show here that LRH-1 promotes the expression of the ste ...[more]