Ontology highlight
ABSTRACT:
SUBMITTER: Stark SE
PROVIDER: S-EPMC2118945 | biostudies-other | 1991 Sep
REPOSITORIES: biostudies-other
The Journal of experimental medicine 19910901 3
We have analyzed how the immune system generates antibodies that are specific for analogues of an epitope on the influenza virus hemagglutinin (HA) that differ solely by the presence of Asp or Gly at amino acid 225. Most antibodies induced in response to HA(Asp225) use one of a few closely related variable (V) region structures that are encoded by characteristic VH/Vk gene segment combinations. Remarkably, none of these VH/Vk combinations was induced in response to HA(Gly225). Instead of modifyi ...[more]