Ontology highlight
ABSTRACT:
SUBMITTER: Shattil SJ
PROVIDER: S-EPMC2120613 | biostudies-other | 1995 Nov
REPOSITORIES: biostudies-other
Shattil S J SJ O'Toole T T Eigenthaler M M Thon V V Williams M M Babior B M BM Ginsberg M H MH
The Journal of cell biology 19951101 3
The adhesive and signaling functions of integrins are regulated through their cytoplasmic domains. We identified a novel 111 residue polypeptide, designated beta 3-endonexin, that interacted with the cytoplasmic tail of the beta 3 integrin subunit in a yeast two-hybrid system. This interaction is structurally specific, since it was reduced by 64% by a point mutation in the beta 3 cytoplasmic tail (S752-->P) that disrupts integrin signaling. Moreover, this interaction is integrin subunit specific ...[more]