Ontology highlight
ABSTRACT:
SUBMITTER: Murphy CT
PROVIDER: S-EPMC2141905 | biostudies-other | 2007 Nov
REPOSITORIES: biostudies-other
Murphy Coleen T CT Lee Seung-Jae SJ Kenyon Cynthia C
Proceedings of the National Academy of Sciences of the United States of America 20071119 48
How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other tissues rises. Here we test the hypothesis that this "FOXO-to-FOXO" signaling occurs via feedback regulation of ins-7 insulin gene expression. We find that DAF-16 regulates ins-7 expression in the in ...[more]