Ontology highlight
ABSTRACT:
SUBMITTER: Stams T
PROVIDER: S-EPMC2143946 | biostudies-other | 1998 Mar
REPOSITORIES: biostudies-other
Protein science : a publication of the Protein Society 19980301 3
Carbonic anhydrase IV (CAIV) is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. We have determined the 2.8-angstroms resolution crystal structure of a truncated, soluble form of recombinant murine CAIV. We have also determined the structure of its complex with a drug used for glaucoma therapy, the sulfonamide inhibitor brinzolamide (Azopt). The overall structure of murine CAIV is generally similar to that of human CAIV; however, some lo ...[more]