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ABSTRACT:
SUBMITTER: Sippel KH
PROVIDER: S-EPMC2765883 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Sippel Katherine H KH Robbins Arthur H AH Domsic John J Genis Caroli C Agbandje-McKenna Mavis M McKenna Robert R
Acta crystallographica. Section F, Structural biology and crystallization communications 20090925 Pt 10
The crystal structure of human carbonic anhydrase II (CA II) complexed with the inhibitor acetazolamide (AZM) has been determined at 1.1 A resolution and refined to an R(cryst) of 11.2% and an R(free) of 14.7%. As observed in previous CA II-inhibitor complexes, AZM binds directly to the zinc and makes several key interactions with active-site residues. The high-resolution data also showed a glycerol molecule adjacent to the AZM in the active site and two additional AZMs that are adventitiously b ...[more]