Ontology highlight
ABSTRACT:
SUBMITTER: Kernebeck T
PROVIDER: S-EPMC2144119 | biostudies-other | 1999 Jan
REPOSITORIES: biostudies-other
Protein science : a publication of the Protein Society 19990101 1
The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR ...[more]