Ontology highlight
ABSTRACT:
SUBMITTER: Gu S
PROVIDER: S-EPMC3308744 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120117 12
The type II secretion system of Gram-negative bacteria is important for bacterial pathogenesis and survival; it is composed of 12 mostly multimeric core proteins, which build a sophisticated secretion machine spanning both bacterial membranes. OutC is the core component of the inner membrane subcomplex thought to be involved in both recognition of substrate and interaction with the outer membrane secretin OutD. Here, we report the solution structure of the HR domain of OutC and explore its inter ...[more]