Unknown

Dataset Information

0

The solution structure of the anti-HIV chemokine vMIP-II.


ABSTRACT: We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which are used by HJV to gain cell entry. vMIP-II is a monomeric protein, unlike most members of the chemokine family, and its structure consists of a disordered N-terminus, followed by a helical turn (Gln25-Leu27), which leads into the first strand of a three-stranded antiparallel beta-sheet (Ser29-Thr34; Gly42-Thr47; Gln52-Asp56). Following the sheet is a C-terminal alpha-helix, which extends from residue Asp60 until Gln68. The final five residues beyond the C-terminal helix (Pro70-Arg74) are in an extended conformation, but several of these C-terminal residues contact the first beta-strand. The structure of vMIP-II is compared to other chemokines that also block infection by HIV-1, and the structural basis of its lack of ability to form a dimer is discussed.

SUBMITTER: Liwang AC 

PROVIDER: S-EPMC2144214 | biostudies-other | 1999 Nov

REPOSITORIES: biostudies-other

altmetric image

Publications

The solution structure of the anti-HIV chemokine vMIP-II.

Liwang A C AC   Wang Z X ZX   Sun Y Y   Peiper S C SC   Liwang P J PJ  

Protein science : a publication of the Protein Society 19991101 11


We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which are used by HJV to gain cell entry. vMIP-II is a monomeric protein, unlike most members of the chemokine family, and its structure consists of a disordered N-terminus, followed by a  ...[more]

Similar Datasets

| S-EPMC3826542 | biostudies-literature
| S-EPMC3853082 | biostudies-literature
| S-EPMC3650389 | biostudies-literature
| S-EPMC5062604 | biostudies-literature
| S-EPMC3973705 | biostudies-literature
| S-EPMC5871641 | biostudies-literature
| S-EPMC5572563 | biostudies-literature
| S-EPMC3819204 | biostudies-literature
| S-EPMC4306592 | biostudies-literature
| S-EPMC1599900 | biostudies-literature