Ontology highlight
ABSTRACT:
SUBMITTER: Tanner JJ
PROVIDER: S-EPMC2144397 | biostudies-other | 1999 Sep
REPOSITORIES: biostudies-other
Tanner J J JJ Tu S C SC Barbour L J LJ Barnes C L CL Krause K L KL
Protein science : a publication of the Protein Society 19990901 9
The 2.1 A resolution crystal structure of flavin reductase P with the inhibitor nicotinamide adenine dinucleotide (NAD) bound in the active site has been determined. NAD adopts a novel, folded conformation in which the nicotinamide and adenine rings stack in parallel with an inter-ring distance of 3.6 A. The pyrophosphate binds next to the flavin cofactor isoalloxazine, while the stacked nicotinamide/adenine moiety faces away from the flavin. The observed NAD conformation is quite different from ...[more]