Ontology highlight
ABSTRACT:
SUBMITTER: Ha S
PROVIDER: S-EPMC2144650 | biostudies-other | 2000 Jun
REPOSITORIES: biostudies-other
Protein science : a publication of the Protein Society 20000601 6
The 1.9 A X-ray structure of a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis is reported. This enzyme, MurG, contains two alpha/beta open sheet domains separated by a deep cleft. Structural analysis suggests that the C-terminal domain contains the UDP-GlcNAc binding site while the N-terminal domain contains the acceptor binding site and likely membrane association site. Combined with sequence data from other MurG homologs, this structure provides insight into the ...[more]