Ontology highlight
ABSTRACT:
SUBMITTER: Barker RL
PROVIDER: S-EPMC2189086 | biostudies-other | 1988 Oct
REPOSITORIES: biostudies-other
Barker R L RL Gleich G J GJ Pease L R LR
The Journal of experimental medicine 19881001 4
Eosinophil granule major basic protein (MBP), a potent toxin for helminths and various cell types, is a 13.8-kD single polypeptide rich in arginine with a calculated isoelectric point (pI) of 10.9. A cDNA for human MBP was isolated from a gamma GT10 HL-60 cDNA library. The nucleotide sequence of the MBP cDNA indicates that MBP is translated as a 25.2-kD preproprotein. The 9.9-kD pro-portion of proMBP is rich in glutamic and aspartic acids and has a calculated pI of 3.9, while proMBP itself has a ...[more]