Ontology highlight
ABSTRACT:
SUBMITTER: Bessette K
PROVIDER: S-EPMC2200817 | biostudies-other | 2008 Jan
REPOSITORIES: biostudies-other
Bessette Katherine K Lang Mark L ML Fava Roy A RA Grundy Martin M Heinen Jennifer J Horne Laurie L Spolski Rosanne R Al-Shami Amin A Morse Herbert C HC Leonard Warren J WJ Kelly John A JA
Blood 20070921 1
Stat5 proteins are critical signaling molecules activated by many cytokines. Within the immune system, Stat5 plays important roles related to the development of thymocytes and proliferation of T cells. Stat5 has been implicated in malignant transformation, and moreover, the activated tyrosine phosphorylated form of Stat5 is frequently observed in human lymphomas. We previously demonstrated the oncogenic potential of Stat5, with thymic lymphoblastic lymphomas developing in a significant proportio ...[more]