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Interleukin 2: from immunostimulation to immunoregulation and back again.


ABSTRACT: Interleukin 2 (IL-2) was one of the first cytokines to be discovered. However, the complex role of IL-2 and its receptor in the regulation of immune responses is only now emerging. This review explores the various signals triggered by IL-2 and discusses their translation into biological function. A model is outlined that accommodates the seemingly contradictory functions of IL-2, and explains how one cytokine can be an essential T-cell growth and differentiation factor and yet also be indispensable to maintain peripheral tolerance.

SUBMITTER: Bachmann MF 

PROVIDER: S-EPMC2267244 | biostudies-other | 2007 Dec

REPOSITORIES: biostudies-other

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