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Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains.


ABSTRACT: Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.

SUBMITTER: Willcocks MM 

PROVIDER: S-EPMC2271283 | biostudies-other | 1995 Apr

REPOSITORIES: biostudies-other

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Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains.

Willcocks M M MM   Kurtz J B JB   Lee T W TW   Carter M J MJ  

Epidemiology and infection 19950401 2


Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region. ...[more]

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