Ontology highlight
ABSTRACT:
SUBMITTER: Nemethova M
PROVIDER: S-EPMC2290848 | biostudies-other | 2008 Mar
REPOSITORIES: biostudies-other
The Journal of cell biology 20080301 6
Filopodia are rodlike extensions generally attributed with a guidance role in cell migration. We now show in fish fibroblasts that filopodia play a major role in generating contractile bundles in the lamella region behind the migrating front. Filopodia that developed adhesion to the substrate via paxillin containing focal complexes contributed their proximal part to stress fiber assembly, and filopodia that folded laterally contributed to the construction of contractile bundles parallel to the c ...[more]