Ontology highlight
ABSTRACT:
SUBMITTER: Torra IP
PROVIDER: S-EPMC2293109 | biostudies-other | 2008 Apr
REPOSITORIES: biostudies-other
Torra Inés Pineda IP Ismaili Naima N Feig Jonathan E JE Xu Chong-Feng CF Cavasotto Claudio C Pancratov Raluca R Rogatsky Inez I Neubert Thomas A TA Fisher Edward A EA Garabedian Michael J MJ
Molecular and cellular biology 20080204 8
Dysregulation of liver X receptor alpha (LXRalpha) activity has been linked to cardiovascular and metabolic diseases. Here, we show that LXRalpha target gene selectivity is achieved by modulation of LXRalpha phosphorylation. Under basal conditions, LXRalpha is phosphorylated at S198; phosphorylation is enhanced by LXR ligands and reduced both by casein kinase 2 (CK2) inhibitors and by activation of its heterodimeric partner RXR with 9-cis-retinoic acid (9cRA). Expression of some (AIM and LPL), b ...[more]