Ontology highlight
ABSTRACT:
SUBMITTER: Han C
PROVIDER: S-EPMC5794762 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180201 1
Chimeric antigen receptor (CAR) T cell therapy is an effective method for treating specific cancers. CARs are normally designed to recognize antigens, which are highly expressed on malignant cells but not on T cells. However, when T cells are engineered with CARs that recognize antigens expressed on the T cell surface, CAR T cells exhibit effector function on other T cells, which results in fratricide, or killing of neighboring T cells. Here, using human leukocyte antigen-DR (HLA-DR)-targeted CA ...[more]