Ontology highlight
ABSTRACT:
SUBMITTER: Jain RG
PROVIDER: S-EPMC231821 | biostudies-other | 1997 Feb
REPOSITORIES: biostudies-other
Jain R G RG Andrews L G LG McGowan K M KM Pekala P H PH Keene J D JD
Molecular and cellular biology 19970201 2
3T3-L1 preadipocytes ectopically expressing the mammalian RNA-binding protein Hel-N1 expressed up to 10-fold more glucose transporter (GLUT1) protein and exhibited elevated rates of basal glucose uptake. Hel-N1 is a member of the ELAV-like family of proteins associated with the induction and maintenance of differentiation in various species. ELAV proteins are known to bind in vitro to short stretches of uridylates in the 3' untranslated regions (3'UTRs) of unstable mRNAs encoding growth-regulato ...[more]