Unknown

Dataset Information

0

Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.


ABSTRACT: We report here the isolation of a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, ESE-1 (for epithelium-specific Ets), which has features distinct from those of any other ets-related factor. ESE-1 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ESE-1 is expressed exclusively in epithelial cells. ESE-1 expression is induced during terminal differentiation of the epidermis and in a primary human keratinocyte differentiation system. The keratinocyte terminal differentiation marker gene, SPRR2A, is a putative target for ESE-1, since SPRR2A expression during keratinocyte differentiation correlates with induction of ESE-1 expression, and ESE-1 binds with high affinity to and transactivates the ets binding site in the SPRR2A promoter. ESE-1 also binds to and transactivates the enhancer of the Endo A gene, a potential target for ESE-1 in simple epithelia. Due to the important role that other ets factors play in cellular differentiation, ESE-1 is expected to be a critical regulator of epithelial cell differentiation.

SUBMITTER: Oettgen P 

PROVIDER: S-EPMC232296 | biostudies-other | 1997 Aug

REPOSITORIES: biostudies-other

altmetric image

Publications

Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.

Oettgen P P   Alani R M RM   Barcinski M A MA   Brown L L   Akbarali Y Y   Boltax J J   Kunsch C C   Munger K K   Libermann T A TA  

Molecular and cellular biology 19970801 8


We report here the isolation of a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, ESE-1 (for epithelium-specific Ets), which has features distinct from those of any other ets-related factor. ESE-1 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factor  ...[more]

Similar Datasets

| S-EPMC2789578 | biostudies-literature
| S-EPMC147045 | biostudies-other
| S-EPMC6597803 | biostudies-literature
| S-EPMC358696 | biostudies-other
| S-EPMC2966119 | biostudies-literature
| S-EPMC3902942 | biostudies-literature
| S-EPMC231510 | biostudies-other
| S-EPMC2486348 | biostudies-literature
| S-EPMC5625037 | biostudies-literature
| S-EPMC7687869 | biostudies-literature