Ontology highlight
ABSTRACT:
SUBMITTER: Oettgen P
PROVIDER: S-EPMC232296 | biostudies-other | 1997 Aug
REPOSITORIES: biostudies-other
Oettgen P P Alani R M RM Barcinski M A MA Brown L L Akbarali Y Y Boltax J J Kunsch C C Munger K K Libermann T A TA
Molecular and cellular biology 19970801 8
We report here the isolation of a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, ESE-1 (for epithelium-specific Ets), which has features distinct from those of any other ets-related factor. ESE-1 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factor ...[more]