Ontology highlight
ABSTRACT:
SUBMITTER: Deane R
PROVIDER: S-EPMC232359 | biostudies-other | 1997 Sep
REPOSITORIES: biostudies-other
Deane R R Schäfer W W Zimmermann H P HP Mueller L L Görlich D D Prehn S S Ponstingl H H Bischoff F R FR
Molecular and cellular biology 19970901 9
We report the identification and characterization of a novel 124-kDa Ran binding protein, RanBP5. This protein is related to importin-beta, the key mediator of nuclear localization signal (NLS)-dependent nuclear transport. RanBP5 was identified by two independent methods: it was isolated from HeLa cells by using its interaction with RanGTP in an overlay assay to monitor enrichment, and it was also found by the yeast two-hybrid selection method with RanBP1 as bait. RanBP5 binds to RanBP1 as part ...[more]